segmented dbs leads vercise cartesiatm directional system model db 2202-45  (Boston Scientific Corporation)

Journal: Brain stimulation

Article Title: Controlling pallidal oscillations in real-time in Parkinson’s disease using evoked interference deep brain stimulation (eiDBS): Proof of concept in the human

doi: 10.1016/j.brs.2022.07.047

Figure Lengend Snippet: (A) Schematic of closed-loop evoked interference DBS. eiDBS delivers stimulation pulses with precise amplitude and timing to evoke resonant neural responses that overrides spontaneous oscillations via constructive or destructive interference. (B) Diagram of directional DBS lead and localization of directional contacts in the GPi adapted from Johnson et al. . The 2D slice in the axial plane is at the depth of ring 3 in the DBS lead. The orthogonal coordinate frame depicted on the axial plane consists of the anterior (A)-posterior (P) and medial (M)-lateral (L) axes. (C) Power spectral density (PSD) of LFPs recorded from contacts 2c-4. (D) Neural responses in the GPi evoked by stimulation in the GPi with currents equal to 0.5, 2.0, and 3.0 mA. (E) Wavelet transform scalogram (time-frequency map) of GPi response evoked by 3 mA stimulation pulses. Regions where the ER is not significantly greater in amplitude than surrogate data are depicted in gray, predominately in the upper right and left hand corners of the scalorgram. Colored regions (not gray) correspond to regions where the ER is significantly greater than surrogate data (p < 0.01). (F) Scatter plot of ER amplitude vs. spontaneous activity amplitude in the 16–22 Hz band as observed across differential recordings from the DBS directional lead. Scalar measures of ER amplitude for each montage are equal to the sum of scalogram values over frequencies in the targeted band (16–22 Hz) at the time where the maximum ER amplitude is observed. Scalar measures of the spontaneous LFP amplitude are equal to the sum of amplitude spectral density (square root of PSD) values over frequencies in the targeted band. R = 0.8 is the correlation coefficient associated with the ER and spontaneous activity data points.

Article Snippet: Following intraoperative microelectrode mapping, a directional DBS lead (Boston Scientific Vercise Cartesia model DB-2202-45; 1.5 mm contact height with 0.5 mm vertical spacing) was implanted.

Techniques: Activity Assay

Journal: Brain stimulation

Article Title: Controlling pallidal oscillations in real-time in Parkinson’s disease using evoked interference deep brain stimulation (eiDBS): Proof of concept in the human

doi: 10.1016/j.brs.2022.07.047

Figure Lengend Snippet: (A) Spectrogram (LFP power in the time-frequency domain) of LFP activity during periods in which eiDBS was delivered to suppress and amplify targeted GPi oscillations in a PD patient implanted with a directional DBS lead. (B) Temporal dynamics of modulated oscillations (filtered in the 17–21 Hz range for clear visualization of modulatory effects on ~19 Hz oscillations) in the off-stimulation to suppression, and suppression to amplification transitions. (C) Mean power spectral density (PSD) of LFP activity in the off-stimulation, suppression, and amplification conditions illustrates how eiDBS modulated spontaneous pallidal oscillations across frequencies. (D) Boxplot with independent measurements (mean over 3 s) of the oscillations’ amplitude envelope in the targeted band (16–22 Hz) in the off-stimulation, eiDBS-suppression, and eiDBS-amplification conditions. The box edges represent the interquartile range, and the horizontal line within each box represents the median. Most extreme data points not considered outliers are represented by the whiskers. The amplitude of oscillations significantly decreased from the off-stimulation to the suppression condition (p = 6.12e-08, Cohen’s U3 effect size = 1) and increased from the off-stimulation to the amplification condition (p = 4.04e-8, Cohen’s U3 effect size = 1). P-values were corrected for the two comparisons made using the Bonferroni method. The symbol ✲ indicates that the difference between conditions was statistically significant with the p-values listed above. The number of independent observations (mean amplitude over 3 s) used in this analysis was n = 16 in the off-stimulation, n = 37 in the suppression, and n = 29 in the amplification condition.

Article Snippet: Following intraoperative microelectrode mapping, a directional DBS lead (Boston Scientific Vercise Cartesia model DB-2202-45; 1.5 mm contact height with 0.5 mm vertical spacing) was implanted.

Techniques: Activity Assay, Amplification